A number of human-mouse somatic cell hybrid closes were examined for the presence or human chromosomes...

90.2K

Verified Solution

Question

Biology

A number of human-mouse somatic cell hybrid closes were examinedfor the presence or human chromosomes and the expression ofspecific human genes. Part of the results are summarized in thetable below. Assign each gene to the chromosome on which it islocated.
Hybrid Cell Lines
5
12
23
30
61
68
Genes Expressed
HBB (defects causes Sickle Cell Anemia)
+
-
-
-
+
+
CFTR (defects causes Cystic Fibrosis)
-
-
+
+
+
+
BRCA1 (defects causes Breast/Ovarian Cancer)
-
-
-
-
-
-
HEXA (defects causes Tay-Sachs Disease)
+
+
-
+
+
-
LRRK2 (defects causes Parkinson's Disease)
-
+
-
+
-
+
Chromosomes (Present or Absent)
16
+
-
+
-
+
-
17
+
-
-
-
+
+
18
+
+
-
+
+
-
19
+
-
+
+
-
+
20
-
-
+
+
+
+
21
-
+
-
+
-
+
22
+
+
+
+
+
+

Answer & Explanation Solved by verified expert

3.8 Ratings (705 Votes)

HBB is located in chromosome 17 CFTR is located in chromosome 20 BRCA1 is located in chromosome 22 HEXA is located in chromosome 18 LRRK2 is located in chromosome 21 Each gene is expressed only when the chromosome is present See Answer

Get Answers to Unlimited Questions

Join us to gain access to millions of questions and expert answers. Enjoy exclusive benefits tailored just for you!

Membership Benefits:

Unlimited Question Access with detailed Answers
Zin AI - 3 Million Words
10 Dall-E 3 Images
20 Plot Generations
Conversation with Dialogue Memory
No Ads, Ever!
Access to Our Best AI Platform: Flex AI - Your personal assistant for all your inquiries!

Become a Member

	Hybrid Cell Lines
	5	12	23	30	61	68
Genes Expressed
HBB (defects causes Sickle Cell Anemia)	+	-	-	-	+	+
CFTR (defects causes Cystic Fibrosis)	-	-	+	+	+	+
BRCA1 (defects causes Breast/Ovarian Cancer)	-	-	-	-	-	-
HEXA (defects causes Tay-Sachs Disease)	+	+	-	+	+	-
LRRK2 (defects causes Parkinson's Disease)	-	+	-	+	-	+
Chromosomes (Present or Absent)
16	+	-	+	-	+	-
17	+	-	-	-	+	+
18	+	+	-	+	+	-
19	+	-	+	+	-	+
20	-	-	+	+	+	+
21	-	+	-	+	-	+
22	+	+	+	+	+	+