A new drug called Xaelenfal is on the market. Xaelenfal is anAMPA receptor antagonist, meaning that it binds onto AMPA receptorswithout activating them and prevents glutamate from binding.

i. If I take the drug Xaelenfal, how will this effect EPSPsrecorded in the postsynaptic neuron when an excitatory presynapticneuron fires an action potential? (1 point)

ii. How will the drug Xaelenfal effect IPSPs in the postsynapticneuron when an inhibitory presynaptic neuron fires an actionpotential? (1 point)

iii. In a normal brain, synapses can get stronger when apresynaptic cell repeatedly causes a postsynaptic cell todepolarize (we call this long-term potentiation, or LTP). Explainhow long term potentiation works including the following details.(3 points)
- Name the neurotransmitter that is released by the presynapticcell.
- Name the receptor that this neurotransmitter binds to on thepostsynaptic cell to mediate normal excitatory transmission.
- What other receptors are involved and how do they getrecruited?
- List one way in which the presynaptic neuron changes and one wayin which the postsynaptic neuron changes during LTP.

iv. Given what you know about plasticity, could Xaelenfal effectthe ability of synapses to potentiate. Explain your answer. (2points)