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A mutation in the liver enzyme PFK-2/FBPase-2 results in the loss of cAMP-dependent kinase phosphorylation site,...

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Biology

A mutation in the liver enzyme PFK-2/FBPase-2 results in theloss of cAMP-dependent kinase phosphorylation site, thus resultingin a loss of responsiveness to cAMP-dependent kinase. What are theeffects of this mutation on blood glucose levels during times offasting? Please explain your answer.

Answer & Explanation Solved by verified expert
4.1 Ratings (703 Votes)
cAMP when binds to regulatory site of protein kinase A itscatalytic subunit gets activated in the active form 1 it inhibitsglycogen synthesis and glycolysis 2 It activates glycogenolysisand gluconeogenesisPFK2FBPase2 is bifunctional enzyme It can synthesize as wellas degrade F26BPWhen    See Answer
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