A mouse model for multiple sclerosis is induced by immunizing mice with murine central nervous system...

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Biology

A mouse model for multiple sclerosis is induced by immunizingmice with murine central nervous system proteins mixed withComplete Freundâ€™s adjuvant. This adjuvant contains components thatstimulate both TLR2 and TLR4. The adjuvant is essential to thedevelopment of autoimmunity because:
a. It activates dendritic cells to up-regulate co-stimulatorymolecules.
b. It prevents the differentiation of CD4 T_H2effector cells.
c. It induces copious amounts of type I interferons.
d. It prevents the production of TGF-b by astrocytes in thecentral nervous system.
e. It promotes tissue damage that mimics a central nervoussystem viral infection.

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The adjuvant is a substance used with a weak antigen to modulate the immune responses It accelerates prolongs or enhance antigenspecific immune responses after combination with See Answer

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