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A cell is defective in succinate dehydrogenase. Will its HIF-1 be hydroxylated by PH-2 under this...

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Biology

A cell is defective in succinate dehydrogenase. Will its HIF-1be hydroxylated by PH-2 under this condition? Justify.

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3.8 Ratings (462 Votes)
Hypoxia inhibitory factor or HIF is composed of HIF1 alpha and HIF 1 beta and is involved in low oxygen condition or hypoxia HIF 1 alpha is degraded in cells under high oxygen concentration However when oxygen levels decline it accumulates in the cell HIF 1 beta levels are constant When oxygen levels are normal normoxia20 oxygen    See Answer
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