A 50 year old male is seen in his physicians office for aroutine check...

A 50 year old male is seen in his physicianâ€™s office for a routine checkup. His...

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Biology

A 50 year old male is seen in his physicianâ€™s office for aroutine checkup. His spleen shows enlargement and his blood workshows hemolytic anemia with bilirubinemia. His wife states thepatient has been â€œoffâ€ lately for no apparent reason. He tends tohave muscle pulsations in the afternoon to late evening that do notstop until he goes to sleep. Additional blood work is ordered alongwith a type and screen. His haptoglobin levels are decreased, andhis physician orders two units of packed RBCs. His antibody screenresults show he has a weakened expression of Kell antigens.
What is the most likely diagnosis?

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3.7 Ratings (636 Votes)

The patient is suffering from autoimmune hemolytic anemia This type of anemia occurs when the patient expresses antibodies to blood group antigens present in its RBCs The Kell group of antigens KEL1KEL24 are highly immunogenic See Answer

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