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A 43 year old man is diagnosed with chronic myeloid leukemia CML and started on...

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A 43 year old man is diagnosed with chronic myeloid leukemia CML and started on standard imatinib therapy tyrosine kinase inhibitor TKI Which of the following clinical findings indicate this therapy protocol is NOT appropriate and should be altered His WBC counts have returned to normal levels O The BCR ABL1 fusion to ABL1 wild type expression mRNA ratio is significantly reduced after 3 months of treatment OPh chromosome is undetectable in bone marrow cells after 9 months of treatment 1 month into therapy and the patient shows an increased frequency of bone marrow cells with the Ph chromosome The expression mRNA ratio of BCR ABL1 ABL1 is down to 0 08 after 18 months of therapy

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