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A 37-year-old man is diagnosed with Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). a. What is the...

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Biology

A 37-year-old man is diagnosed with Philadelphiachromosome-positive (Ph+) chronic myelogenous leukemia (CML).

a. What is the molecular mechanism that makes this kind ofcancer?(1/2 page)

b. What is the first-line treatment for CML and what is therationale for this pharmacotherapy?(1/4 page)

c. What are the mechanisms of resistance to imatinibpharmacotherapy of CML?(1/4 page)

d. What other cancers and diseases are effectively treated withimatinib?(1/4 page)

e. What are the common and important side effects of therapywith imatinib(1/4 page)

Answer & Explanation Solved by verified expert
3.6 Ratings (287 Votes)
1 There occurs translocation from chromocome number 9 to number 12 This leads to BCRABL fusion BCR ABL fusion leads to a constitutive tyrosine kinase which would carry out the    See Answer
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