9 What do you think would happen consider clotting phenotype if a male carried both a null F8 hemophilia causing allele F8 such as the one presented above and a F9 thrombosis causing alle on his X chromosome You may want to consult the clotting pathway shown below from http www ncbi nlm nih gov books NBK22589 rendertype figure id A1401 and recall that F8 is als called VIIla and F9 is also called IX inactive form and IXa active form Essentially the factors show in pink are inactive until the factor in the cascade above them becomes active yellow Then the activ factor above them will convert the pink inactive form to its active form to perform its function on the ne protein in the cascade For instance 1 there is damage to the skin 2 inactive XII gets converted to active form Xlla Xlla converts inactive XI to active Xia The cascade progressed through each step until a cross linked fibrin clot occurs at the end assuming there are functional proteins at each step in the cascade INTRINSIC PATHWAY Damaged surface XII Kininogen Kallikrein XI XII IX FINAL COMMON PATHWAY XI IX VIII Prothrombin ID X V Fibrinogen 1 EXTRINSIC PATHWAY VIIa Trauma Tissue factor X Thrombin 11 VII Figure 10 37 Blood Clotting Cascade Fibrin 6 XIII Trauma Cross linked fibrin clot