7. Discuss the primary issues associated with protein
folding.
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Chemistry
7. Discuss the primary issues associated with proteinfolding.
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The protein folding problem consists of three closely related puzzles a What is the folding code b What is the folding mechanism c Can we predict the native structure of a protein from its amino acid sequence Once regarded as a grand challenge protein folding has seen great progress in recent years Now foldable proteins and nonbiological polymers are being designed routinely and moving toward successful applications The structures of small proteins are now often well predicted by computer methods And there is now a testable explanation for how a protein can fold so quickly A protein solves its large global optimization problem as a series of smaller local optimization problems growing and assembling the native structure from peptide fragments local structures first 1 The Folding Code The starting point of protein folding is indeed the primary structure the sequence of amino acids also known as denatured state of the protein Even the smallest amount of the denatured state can activate nucleation and proliferation
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