5 The major protein component of human hair is a keratin Hair straighteners are commonly used tools which use heat to iron hair into temporarily lying flat and straight What is the best biological explanation for this phenomenon A Hair straighteners disrupt ionic bonds between a keratin molecules B Hair straighteners denature proteins by disrupting the pH C Hair straighteners disrupt hydrogen bonds in a keratin D Hair straighteners disrupt disulfide bridges in a keratin 4 6 Creutzfeldt Jakob Disease CJD is a degenerative neurological disorder Biopsy of the the brains of affected individuals reveals aggregations of a prion protein a protein which is capable of folding into multiple structurally distinct forms In CJD two versions of the offending protein have been identified The normal form is predominantly composed of alpha helix while the variant has significant beta structure The beta structure presumably has more solvent accessible hydrophobic groups lacking a polar outer layer Knowing only this how might you differentiate between the normal and variant conformations given a sample of each in the lab A Attempt to dissolve both samples in water knowing that if it dissolves it is the normal protein B Determine the mass of the crystallized structure of a single molecule of each sample knowing that the heavier of the two is the normal protein C Denature each sample with heat and analyze the polypeptide chains by NMR D Determine the polypeptide sequence of each sample and compare them to a known database