5. A patient with chronic-stable angina begins takingmetoprolol, and once blood levels reach the therapeutic range thefrequency and severity of angina attacks and the need forsublingual nitroglycerin were reduced. Which of the followingstates the direct pharmacologic action by which the beta-blockerproduced the desired effects? A. Decreased myocardial oxygendemand

B. Dilated coronary vasculature

C. Directly inhibited angiotensin II synthesis

D. Reduced total peripheral resistance

6. A patient with newly diagnosed essential hypertension startstreatment with a commonly used antihypertensive drug at a dose thatis considered to be therapeutic for the vast majority of patients.Soon after starting therapy the patient experiences crushing chestdiscomfort. ECG changes show myocardial ischemia. Studies in thecardiac catheterization lab show episodes of coronary vasospasm,and it is likely the antihypertensive drug provoke the vasospasm.Which antihypertensive drug most likely caused the ischemia and theangina?

A. Atenolol

B. Diltiazem

C. Hydrochlorothiazide

D. Lozartan

7. A 28-year-old woman is receiving drug therapy for essentialhypertension. She subsequently becomes pregnant. You realize thatthe drug she's been taking for her blood pressure can have serious,if not fatal, effects on the fetus. As a result, you stop thecurrent antihypertensive drug and substitute it with another drugthat is deemed to be equally effective in terms of her bloodpressure, and safer for the fetus. Which of the following drugs wasshe most likely taking before she became pregnant?

A. Alpha-Methyldopa

B. Captopril

C. Furosemide

D. Labetalol E. Verapamil

8. The use of propranolol as an antiarrhythmic agent iscontraindicated in patients with:

A. COPD

B. Asthma

C. Severe heart failure

D. A and C

E. All of the above