4a. Using SARS-CoV as a specific example, describe how
epidemiologists can track infections during an
epidemic by...
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Biology
4a. Using SARS-CoV as a specific example, describe howepidemiologists can track infections during an epidemic by a) measuring antibody levels (seroconversion) and b)using PCR methods. 4b. During the course of a single infection, which method willdetect SARS-CoV earliest? Explain why.
Answer both questions thoroughly andcompletely
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4a During the SARSCoV outbreak rapid diagnosis was best made by RTPCR using defined primers usually derived from the viral N sequence For early diagnosis specimens from throat or nasal pharyngeal swabs can be used for RTPCR and serum samples were also used to detect viral RNA during the first week of illness Both stool and respiratory specimens were assayed for viral RNA during the second week of illness In contrast serological assays usually provide the best way to confirm or rule out infections ex post facto EIAs for viral N and S
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