4. The rate with which enzymes can transform a substrate variesfrom enzyme to enzyme, and sometimes substrate to substrate. a) Howare competitive and uncompetitive reversible inhibition similar?How is their effect on rate different? b) Enzyme reaction ratesdrop off dramatically as temperatures pass 50 °C or so, and do notreturn to their previous rate when cooled. Explain the drop off inactivity and the lack of return to the previously higher reactionrates after heating. c) Pepsin is an enzyme that participates indigestion in the stomach, whereas trypsin is an enzyme thatparticipates in digestion in the small inestines. Pepsin has thehighest turnover number at around pH 2, whereas trypsin has thehighest turnover number around pH 8. Explain this difference.