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4 In Chapter 4 we saw that the small probability for error during replication can...

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4 In Chapter 4 we saw that the small probability for error during replication can result in mutations that change the function of a gene Certain mutations in the E coli rpsL gene result in the phenotype of resistance to the antibiotic streptomycin Similarly specific mutations in the rpos gene yield rifampicin resistant varieties The antibiotics have distinct mechanisms of action so that a bacterial cell might be resistant to one both or neither When 108 of a certain strain of mismatch repair deficient E coli bacteria from a rapidly dividing culture are plated onto nutrient agar plates containing streptomycin 119 resistant colonies each arising from a single cell are obtained When the same number of bacteria are plated out on plates containing rifampicin 35 colonies are counted What is the probability of obtaining a colony resistant to both streptomycin and rifampicin

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