2,3 BPG is quite abundant in red blood cells (~4.5 mM) and it modulates the affinity...

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Chemistry

2,3 BPG is quite abundant in red blood cells (~4.5 mM) and itmodulates the affinity of hemoglobin for oxgen. Briefly explainwhat BPG is doing to the affinity of hemoglobin for oxygen.

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23BPG binds to hemoglobin in the center of the tetramer to stabilize the T state Eg in muscle tissues 23BPG is also extremely important in the role of stabilizing the T state of hemoglobin The hemoglobin wants to change into a more favorable R state due to the fact that the T state is quite unstable Pure hemoglobin without 23BPG was tested and found to bind oxygen much more vigorously than hemoglobin in blood A hemoglobin with 23BPG has a lower affinity for oxygen binding in the tissue which allows See Answer

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