2. Outline essential structural features a 1,4-Dihydropyridine must possess for effective Ca2+ channel blocking capability. Why are...

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Chemistry

2. Outline essential structural features a 1,4-Dihydropyridinemust possess for effective Ca2+ channel blocking capability. Whyare dimethyl 1,4-Dihydro-2,6-Dimethylpyridine-3,5-Dicarboxylate anddiethyl 1,4-Dihydro-2,6-Dimethylpyridine-3,5-Dicarboxylateineffective in this regard?

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14Dihydropyridine DHP animportant class of calcium antagonist inhibits the influx ofextracellular Ca2 through Ltype voltagedependent calciumchannels Generally speaking DHPs can be prepared via the Hantzschmethodology reduction of or addition to appropriate pyridines andseveral cycloaddition reactionsThe presence of 14DHP ring as anessential moiety for calcium antagonist activity has been assuredin many literatures This important class of calcium channelantagonists has been proven to act by decreasing the passage of thetransmembrane calcium current on binding causing a long See Answer

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