1.Normal fertilization requires changes in the membrane organization of both sperm and oocyte and penetration of...

60.1K

Verified Solution

Question

Biology

1.Normal fertilization requires changes in the membraneorganization of both sperm and oocyte and penetration of the oocyteby a single spermatozoon.
a. What physical, cellular and biochemical molecular processesare necessary for the succesful passage of a spem from theoutermost portion of the cumulus oophorus to the oocytemembrane?
b. How does the human sperm nucleus move in the cytoplasm andwhy does it facilitate the juxtaposition of the material andpaternal pronuclei?
c. why is the orientation of pronuclear DNA critical forembryogenesis to proceed and how does it promote pronuclearmembrane breakdown (syngamy)
d. What specific defects in the above processes have been shownto result in fertilization or early developmental failure?

Answer & Explanation Solved by verified expert

4.3 Ratings (611 Votes)

a Cellular and biochemical molecular processes are necessary for the succesful passage of a spem from the outermost portion of the cumulus oophorus to the oocyte membrane Capacitation 1The sperm cell membrane is altered by the removal of cholesterol by albumin proteins this changes the position of lipid rafts hich now cluster over the anterior sperm head These lipid microdomains contain proteins that can bind the zona pellucida 2 Protein phosphorylation occurs two chaperone heatshock proteins migrate to the surface of the sperm head when they are phosphorylated Here they may play an essential role in forming the receptor that binds to the zona See Answer

Get Answers to Unlimited Questions

Join us to gain access to millions of questions and expert answers. Enjoy exclusive benefits tailored just for you!

Membership Benefits:

Unlimited Question Access with detailed Answers
Zin AI - 3 Million Words
10 Dall-E 3 Images
20 Plot Generations
Conversation with Dialogue Memory
No Ads, Ever!
Access to Our Best AI Platform: Flex AI - Your personal assistant for all your inquiries!

Become a Member