1)List the B-cell developmental stages from pre-pro toimmature B cells describing B-cell receptor (BCR or Ig)rearrangements occurring and/or key events occurring at eachstage.
2)What is the role of Artemis in V(D)J recombination andwhy is it important?
3)During B-cell activation some activatedB-cells undergo differentiation into antibody secreting plasmacells outside of the germinal center and therefore never go throughthe germinal center responses. Other activated B-cells will returnto the follicle forming a germinal center and undergo processesthat alter the antibody that will beproduced.  Describe the germinal centerresponses. Why are these responses important (hint: what isdifferent about the antibody produced)? Why are T cells importantin germinal center responses?
