10.5. Provide the graphs for the Lineweaver-Burk for Competitive, Non-competitive, and Un-competitive inhibition and describe what occurs to...

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Chemistry

10.5. Provide the graphs for the Lineweaver-Burk forCompetitive, Non-competitive, and Un-competitive inhibitionand
describe what occurs to Km and Vmax for each.

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Lets imagine that youre in the market for a sports car What might you want to know about your various options Ferrari Porsche Jaguar etc to decide which one is best One obvious factor would be how fast the car can go when you floor it But you might also want more finegrained information on cars performance such as how quickly it can accelerate from 0 to 60 mph In other words instead of just knowing its maximum speed youd also want to know the kinetics of how the car reaches that speed Biochemists tend to feel similarly about the enzymes they study They want to know as much as possible about an enzymes effects on reaction rate not just how fast the enzyme can go in a flatout scenario As a matter of fact you can tell a remarkable amount about how an enzyme works and about how it interacts with other molecules such as inhibitors simply by measuring how quickly it catalyzes a reaction under a series of different conditions The information from these experiments is often presented in the form of graphs so well spend a little time here discussing how the graphs are made and how to read them to get the most out of them Basic enzyme kinetics graphs Graphs like the one shown below graphing reaction rate as a function of substrate concentration are often used to display information about enzyme kinetics They provide a lot of useful information but they can also be pretty confusing the first time you see them Here well walk step by step through the process of making and interpreting one of these graphs Enzyme kinetics graph showing rate of reaction as a function of substrate concentration Enzyme kinetics graph showing rate of reaction as a function of substrate concentration Image modified from Enzymes Figure 3 by OpenStax College Biology CC BY 30 See Answer

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