10. Consider a mutant strain of a pathogen that is unable to produce siderophores. What likely impact...

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Biology

10. Consider a mutant strain of a pathogen that is unable toproduce siderophores. What
likely impact would this have on the mutant pathogen during aninfection?
11. Describe some general damaging effects of an infection.
12. Define, compare, and contrast exotoxins and endotoxins.
13. Describe the three classes of exotoxins and their mode ofaction.

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3.7 Ratings (331 Votes)

A 10 Iron is essential for almost all living organisms including bacteria The ability of pathogenic bacteria to acquire iron in hosts is absolutely essential for bacterial growth and infection In animal hosts iron is usually bound to proteins such as transferrin and lactoferrin in extracellular fluid and to ferritin hemoglobin and hemecontaining enzymes in cells To utilize such complexes as iron sources bacteria generally possess some sophisticated mechanisms which include an iron uptake system mediated by highaffinity iron chelators called siderophores However mutated pathogens who have lost the ability to produce sideropohores would not survive in host due to inability to acquire iron and hence would be unable to produce infection A 11 An infection happens when a foreign organism enters a persons body and causes harm Different types of bacteria viruses fungi protozoa parasites and prions cause infections Depending on the infection the body can be affected minimally or severely In a viral cold infection the body may feel general discomfort and illness for a short period of time The EpsteinBarr viral infection however can cause the body to become extremely exhausted which can last for months in some cases Other infections can cause fevers pain and weight loss Pathogenic microbes challenge the immune system in many ways Viruses make us sick by killing cells or disrupting cell functionSome viruses target skin cells causing warts Others target a wider range of cells leading to various symptoms A flu virus can cause a runny nose muscle aches and an upset stomach Sometimes bacteria multiply so rapidly they crowd out host tissues and disrupt normal function Sometimes they kill cells and tissues outright Sometimes they make toxins that can paralyze destroy cells metabolic machinery or precipitate a massive See Answer

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