1) Which ONE of the following is NOT TRUE about p16:
a)it is an oncogene
b)it is on the same pathway and hence seldom mutated in tumors whenRB is
c)it is often mutated in cancers such as familial melanoma
d)it is encoded in the same gene locus as p19-ARF
e)It is a cyclin dependent kinase inhibitor (CKI)
2)Which ONE of the following is NOT a property of thetransformed phenotype:
a)Induced by over expression of tumor suppressor genes
b)Anchorage independence
c)Infinite proliferative life span
d)Lower requirement for growth factors
e)Does not exhibit density-dependent inhibition of cellgrowth
3)Which ONE of the following is NOT true about DNA viruses andcancer:
a)HPV E6, HPV E7 and SV40 large T antigen are all viraloncoproteins encoded by DNA viruses
b)they encode viral oncoproteins that bind RB
c)viral oncoproteins do not originate from host genes
d)they encode viral oncoproteins that bind MDM2
4) Which ONE of the following is NOT TRUE about the JNKpathway:
a)Another name for the pathway is the stress activated pathway(SAPK)
b)JNK stands for Jun N-terminal kinase
c)It is activated by UV and osmolarity changes
d)it does not require scaffolding proteins for propersignaling
e)it is affected by phytochemicals such as resveratrol
5)Which ONE of the following is NOT TRUE about the onlineresources The Cancer Genome Atlas (TCGA) and cBioPortal:
a)they can help researchers understand the molecular basis ofcancer
b)they can help distinguish tumor subtypes for betterdiagnosis
c) they allow many scientists around the world to access thedata and further cancer research
d) they can help the average person diagnose themselves in thecomfort of their own home
e) they can help identify genomic characteristics of tumors toimprove treatment
6) Which ONE of the following statements is NOT TRUE about Rassignaling:
a)GEFs (guanine nucleotide exchange factors) convert inactiveRas to active Ras
b)Ras was identified in both the NIH 3T3 foci assay and as aviral oncogene
c)active Ras recruits Raf to the inner plasma membrane
d)~50% of Ras is bound to GTP in the active state in a normalcell
e)prenylation of its C-terminal tail is required for both wt andmutant Ras to be functional
