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1. Which of the following transcription factor complexes is activated by Jak upon interferon (cytokine) activation? a. NF-kB b. Smads c. STATs d. c-Jun e. CREB 2....

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Biology

1. Which of the following transcription factor complexes isactivated by Jak upon interferon (cytokine) activation?

a.NF-kB
b.Smads
c.STATs
d.c-Jun
e.

CREB

2. Interactions between intracellular signaling proteins aremediated by modular binding domains. Which of the following domainbinds to a proline rich region?

a.PH
b.SH2
c.PPP
d.PTB
e.

SH3

3. Discussing PI 3-kinase: which of the following statements iscorrect?

a.can directly phosphorylate phospholipase C-γ to produce DAG andIP3
b.phosphorylates PI(4,5)P2 to produce PI(3,4,5)P3 that functionsas docking sites for downstream proteins with a SH2 domain
c.phosphorylates DAG to produce PI(3,4,5)P3 that functions asdocking sites for downstream proteins with a SH3 domain
d.phosphorylates PI(4,5)P2 to produce IP3 that functions asdocking sites for downstream proteins with a PTB domain
e.phosphorylates PI(4,5)P2 to produce PI(3,4,5)P3 that functionsas docking sites for downstream proteins with a PH domain

Answer & Explanation Solved by verified expert
4.0 Ratings (505 Votes)
1 a NFkB explanation NFkB is not involved in JAKSTAT pathway Hence option a is incorrect b Smads smads is not onvolved JAKSTAT pathways Hence option b is incorrect c STAT explanation JAK Janus Kinase family so called Nontyrosine receptor kinase and STAT for signal transducer and activator of transcription Hence option c is correct d cJun explanation Generally cJun combined    See Answer
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