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1. True/False: Individuals with mutations in the genes encoding the IL-12p40 subunit (shared by IL-12 and...

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Biology

1. True/False: Individuals with mutations in the genes encodingthe IL-12p40 subunit (shared by IL-12 and IL-23) are susceptible tonot only pathogens such as M. tuberculosis that require a Th1response, but type 3 (Th17) responses are also affected.

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True RNAactivated APCs secrete IL12 a major cytokine to generateTh1 response thereby causing pathogenesis of TB Though the most active form is IL12p70 produced by DCs macrophages    See Answer
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