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1 The F8 gene codes for a protein that is necessary for blood clotting and...

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1 The F8 gene codes for a protein that is necessary for blood clotting and is made mainly by liver cells The bloodstream normally contains inactive F8 along with another inactive coagulation factor called F9 In injured tissues the F8 and F9 proteins interact to form an active complex that initiates a chain of reactions that lead to the formation of a blood clot Deficiencies in F8 or F9 cause hemophilia a failure of the blood to clot normally You can find more information about the F8 gene here http ghr nlm nih gov gene F8 https www genecards org cgi bin carddisp pl gene F8 and the F9 gene here https ghr nlm nih gov gene F9 normalfunction https www genecards org cgi bin carddisp pl gene F9 keywords f9 Coagulation factors F8 and F9 are also known as Factor VIII and Factor IX respectively a What can you find out about the size of the F8 and F9 genes from the websites above Where are these gene located see gene cards links and scroll down b Draw the two X chromosomes of a female and the X and Y of a male Label the approximate locations of the F8 and F9 loci If you need a brief refresher on X linked inheritance see here https www cancer gov publications dictionaries genetics dictionary def x linked recessive inheritance

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