1. let's say CFTR (encoding the CFTR Cl- channel) has twoalleles: + (which encodes a functional product) and - (whichencodes a non-functional product). CFTR is a Cl- transporterexpressed in many epithelial cells. LDLR is on chromosome 7. Aperson with the -/- genotype has Cystic Fibrosis but those witheither +/- or +/+ genotypes do not. Which of the following istrue?
| | a. Cystic Fibrosis is autosomal recessive because a person musthave two copies of the \"-\" allele to express the phenotype |
| | b. Cystic Fibrosis is autosomal dominant because the \"+\" alleleis the normal version |
| | c. Cystic Fibrosis is autosomal dominant because the \"+\" alleleis the most common in the population |
| | d. Cystic Fibrosis is autosomal dominant, because a person musthave two copies of the \"-\" allele to express the phenotype |
| | e. Cystic Fibrosis is autosomal recessive because it is the \"-\"allele that causes the disease |
2.
let's say SLC2A4 (encoding the insulin-dependent glucosetransporter GLUT4) has two alleles: + (which encodes a functionalproduct) and - (which encodes a non-functional product). If GLUT4expression is necessary to not have diabetes,which of the following can we definitely conclude? (More than oneanswer may seem correct but only one answer logically follows theinformation)
| | a. a +/- genotype will have a mild form of diabetes |
| | b. a -/- genotype will have diabetes |
| | c. a -/- genotype may not have diabetes |
| | d. a +/- genotype will have a 50% probability of diabetes |
| | e. a +/+ genotype will not have diabetees |
3.
a pretty good definition of a gene is
| | a. one of the homologous chromosome inherited from either theegg (mother) or sperm (father) |
| | b. a discrete segment of DNA that encodes a functionalproduct |
| | c. one of two or more alternative forms of nucleotide that ariseby mutation and are found at the same place on a chromosome. |
| | d. the mRNA that is translated into a polypeptide |
| | e. the bluprint for the phenotype |
4.
In the chart:
| A | B | C | D |
|---|
| +/+ | 100% functional protein | watery | no disease |
| +/- | 50% functional protein | intermediate | no disease |
| -/- | 0% functional protein | thick | disease |
What is in column A?
| | a. different genes |
| | b. different phenotypes |
| | c. different genotypes |
| | d. different loci |
| | e. different proteins |
