1. Graves' disease is a condition in which some of the body's antibodies mimic the function...

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1. Graves' disease is a condition in which some of thebody's antibodies mimic the function of thyroid-stimulating hormoneand cause over activity of the thyroid gland. what consequenceswould this have on a patient's overall metabolic rate and theirability to maintain a healthy weight? would you expect someone withGraves' disease to have a higher or lower average core bodytemperature compared to someone who was unaffected?
2. when fatty acids are metabolized for cellularrespiration, the first step involves breaking two carbons at a timeoff the chain to form of acetyl - CoA. This acetyl- CoA than:
3. Stenosis (constriction) of the pyloric sphincterwould interfere with:
4. Any organ which helps break down food but is notpart of the tube through which the foodstuffs pass is referred toas a(n):
5. At the corners of each hepatic lobule are threevessels, collectively known as the portal triad. what vessels makeup this group?
6. The main part of the stomach is called the:

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1 GRAVES DISEASEGraves disease is the most common cause of endogenoushyperthyroidism It is characterized by a triad ofmanifestations Thyrotoxicosis caused by a diffusely enlarged hyper functionalthyroid An infiltrative ophthalmopathy with resultant exophthal mosnoted in as many as 40 of patients A localized infiltrative dermopathy sometimes desig natedpretibial myxedema seen in a minority of casesPathogenesis of Graves DiseaseMany manifestations of Graves disease are caused byautoantibodies against the TSH receptor that bind to andstimulate thyroid follicular cells independent of endogenoustrophic hormones Multiple autoantibodies are produced in Gravesdisease including the following Thyroidstimulating immunoglobulin TSI This IgG antibodybinds to the TSH receptor and mimics the action of TSH stimulatingadenyl cyclase with resultant increased release of thyroidhormones Almost all indi viduals with Graves disease havedetectable amounts of this autoantibody which is relativelyspecific for Graves disease Thyroid growthstimulating immunoglobulins Also directedagainst the TSH receptor these antibodies have been implicated inthe proliferation of thyroid follicular epithelium TSHbinding inhibitor immunoglobulins These antiTSH receptorantibodies prevent TSH from binding to its See Answer

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