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1) Explain the molecular mechanism of action of H1-receptor antagonists- 2) Explain the molecular mechanism of action...

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Medical Sciences

1) Explain the molecular mechanism of action of H1-receptorantagonists-

2) Explain the molecular mechanism of action of H2-receptorantagonists

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3.7 Ratings (429 Votes)
H1 receptors are G proteincoupled receptors Gq which operate through PhospholipaseIP3DAGpathway The agonist histamine binds to its H1 receptor andactivates the G protein Gq Its alpha subunit binds GTP in placeof GDP dissociates from the receptor as well as from betagammadimer to activate membrane bound phospholipase c that hydrolysesphosphatidyl inositol 45bisphosphate PIP2 a    See Answer
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