1) A total of 6147 North American Caucasians were blood typedfor the MN locus, which is determined by two codominant alleles,L^M and L^N. The following data wereobtained:

Bloodtype                    Number

      M                              1654

    MN                             3215

      N                              1278

Carry out a chi-square test to determine whether this populationis in Hardy–Weinberg equilibrium at the MN locus.

2) Tay–Sachs disease is an autosomal recessive disorder. AmongAshkenazi Jews, the frequency of Tay–Sachs disease is 1 in 2400. Ifthe Ashkenazi population is mating randomly for the Tay–Sachs gene,what proportion of the population consists of heterozygous carriersof the Tay–Sachs allele?

3) Color blindness in humans is an X-linked recessive trait. Inmost populations, we saw that approximately 10% of the men arecolorblind, however in a unique region on a remote island thepresence of color blind men is closer to 15% (6 points)

a. If mating is random for the color-blind locus, what is thefrequency of the color-blind allele in this unique population?

b. What proportion of the women in this population is expectedto be colorblind?

c. What proportion of the women in the population are expectedto be heterozygous carriers of the color-blindness allele?